反应详情

To a solution of N-[2-(4-cyclopropylpiperazin-1-yl)benzothiazol-6-yl]-acetamide (679 mg, 2.15 mmol) in EtOH (36 mL) was added concentrated hydrochloric acid (7.2 mL). The mixture was heated at reflux for 2 h. After cooling, the mixture was neutralized with 15% sodium hydroxide. The volatiles were removed under reduced pressure and the residue was dissolved in methanol (10 mL). The mixture was filtered and the filtrate was concentrated in vacuo to give 512 mg (87%) of 2-(4-cyclopropylpiperazin-1-yl)benzothiazol-6-ylamine.

1. temperatureThe mixture was heated
2. temperatureat reflux for 2 h
3. temperatureAfter cooling
4. customThe volatiles were removed under reduced pressure
5. dissolutionthe residue was dissolved in methanol (10 mL)
6. filtrationThe mixture was filtered
7. concentrationthe filtrate was concentrated in vacuo