反应详情

To a solution of 5-bromobenzo[d]thiazole-2-thiol (24 mg, 0.098 mmol) in EtOH (1.5 mL) was added triethylamine (10 mg, 0.098 mmol) and methyliodide (14 mg, 0.098 mmol). The mixture was heated at reflux for 1.5 h. Then the mixture was extracted with dichloromethane (3×10 mL). The combined organic extracts were washed with brine, dried (Na2SO4) and concentrated to give 5-bromo-2-(methylthio)benzothiazole 20 mg (80%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1.5 h
3. extractionThen the mixture was extracted with dichloromethane (3×10 mL)
4. washThe combined organic extracts were washed with brine
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated