Hydroxide → 2-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

HRID 194469Notes

Reaction equation

HRID 194469 reaction equation
[CH3:14][CH2:15][O:16][C:17]([CH3:18])=[O:19].[O:1]1[CH2:2][CH2:3][C:4]([c:7]2[n:8][cH:9][cH:10][n:11][c:12]2[F:13])=[CH:5][CH2:6]1.[OH-:20].[OH-:22].[Pd+2:21]>>[O:1]1[CH2:2][CH2:3][CH:4]([c:7]2[n:8][cH:9][cH:10][n:11][c:12]2[F:13])[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 593511782-(3,6-dihydro-2H-pyran-4-yl)-3-fluoropyrazine

Product 1

HCID 593512282-fluoro-3-(Tetrahydro-2H-pyran-4-yl)pyrazine

Sources & evidence

ORD record
ord-e6af67eea342410bbdfecdb38627eb4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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