Hydrochloric Acid → 2-Thioxo-2,3-dihydro-1,3-benzoxazole-5-carbonitrile

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Reaction Steps

A mixture of 3-amino-4-hydroxybenzonitrile (50 mg, 0.37 mmol) and potassium O-ethyl-xanthate (65 mg, 0.41 mmol) in pyridine (0.75 mL) was heated at reflux for 2 h. After cooling, the mixture was poured into ice-water. Then concentrated hydrochloric acid (0.2 mL) was added. The solid was collected, washed with water and dried to give 2-thioxo-2,3-dihydrobenzooxazole-5-carbonitrile 30 mg (46%).

Provenance & Evidence