Hydrochloric Acid → HCID 178463346, compound

Participants

Reaction Steps

Methyl trans-4-(4-chloro-3-(ethylamino)phenylsulfonamido)cyclohexane-carboxylate (Intermediate 12, 220 mg, 0.552 mmol) in 1/1/1 THF/MeOH/1N LiOH was warmed to 45° C. overnight. The reaction was cooled to room temperature, then acidified to pH 3 with 1N HCl and extracted with multiple volumes EtOAc. The combined organic layers were dried over sodium sulfate, filtered and concentrated to give the title compound as colorless solid (169 mg, 0.468 mmol, 85% yield). MS MH+ 361.2

Provenance & Evidence