HRID1944708

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCNc1cc(S(=O)(=O)N[C@H]2CC[C@H](C(=O)OC)CC2)ccc1Cl

HCID178463347

未命名化合物

2 次

PRODUCTS

生成物

结构：CCNc1cc(S(=O)(=O)N[C@H]2CC[C@H](C(=O)O)CC2)ccc1Cl

HCID178463346

未命名化合物

收率 85%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21899815

未命名化合物

PROCEDURE

实验过程

Methyl trans-4-(4-chloro-3-(ethylamino)phenylsulfonamido)cyclohexane-carboxylate (Intermediate 12, 220 mg, 0.552 mmol) in 1/1/1 THF/MeOH/1N LiOH was warmed to 45° C. overnight. The reaction was cooled to room temperature, then acidified to pH 3 with 1N HCl and extracted with multiple volumes EtOAc. The combined organic layers were dried over sodium sulfate, filtered and concentrated to give the title compound as colorless solid (169 mg, 0.468 mmol, 85% yield). MS MH+ 361.2

WORKUP

后处理

extractionextracted with multiple volumes EtOAc
dry with materialThe combined organic layers were dried over sodium sulfate
filtrationfiltered
concentrationconcentrated