Trifluoroacetic acid → HCID 59264546, compound

HRID 1944717Notes

Reaction equation

HRID 1944717 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C@@H:5]([NH:12]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][CH2:3][CH2:4][C@H:5]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[NH2:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57791175HCID 57791175, compound2×

Product 1

HCID 59264546HCID 59264546, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-tert-Butyl 3-methoxy-1-phenylpropylcarbamate (Intermediate 61, 78 mg, 0.294 mmol) was dissolved in DCM (4.5 ml) and TFA (0.5 ml) was added. The reaction mixture was stirred for 1 h at room temperature when LCMS indicated that the reaction was complete. The reaction mixture was concentrated in vacuo, and the crude product was taken onto next step without further purification (0.294 mmol). LCMS [M+H]=166

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe crude product was taken onto next step without further purification (0.294 mmol)

Sources & evidence

ORD record
ord-d4c43da7970f4d3297495ebb8685d3c2
Source dataset
uspto-grants-2013_03
Patent number
US08394858B2

Reaction notes

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