Ethyl 4-(1,3-dioxoisoindolin-2-yl)-1-methylcyclohexanecarboxylate → 1-Allyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-cyclohexanecarboxylic acid ethyl ester

HRID 1944721Notes

Reaction equation

HRID 1944721 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH:12]1[CH2:17][CH2:16][C:15]([CH3:23])([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH2:14][CH2:13]1.[CH2:24](C1(C(OCC)=O)CCC(O)CC1)[CH:25]=C>>[CH2:21]([O:20][C:18]([C:15]1([CH2:23][CH:24]=[CH2:25])[CH2:16][CH2:17][CH:12]([N:3]2[C:4](=[O:11])[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[C:2]2=[O:1])[CH2:13][CH2:14]1)=[O:19])[CH3:22]

Participants

3

Reactant 2

HCID 58074352Ethyl 4-(1,3-dioxoisoindolin-2-yl)-1-methylcyclohexanecarboxylateHCID 67225352Ethyl 1-allyl-4-hydroxycyclohexanecarboxylate2×

Product 1

HCID 672250981-Allyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-cyclohexanecarboxylic acid ethyl ester

Procedure

The title compound was prepared by a method analogous to the method used to prepare Intermediate 72 using ethyl 1-allyl-4-hydroxycyclohexanecarboxylate (Intermediate 99) as the starting material.

Sources & evidence

ORD record
ord-6cd81255fb534f338c703b43c55ce99e
Source dataset
uspto-grants-2013_03
Patent number
US08394858B2

Reaction notes

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