huagongshe.com
HRID1944730

反应详情

EQUATION

反应方程式

HRID 1944730 的结构方程式

REACTANTS

反应物

3
结构：C[C@@H](N)c1ccc(F)cc1
HCID6950187

(R)-1-(4-fluorophenyl)ethanamine

C8H10FN

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CC(C)(C)OC(=O)NC1(C(=O)O)CCC(=O)CC1
HCID24729768

1-[(tert-Butoxycarbonyl)amino]-4-oxocyclohexane-1-carboxylic acid

C12H19NO5

PRODUCTS

生成物

1
结构：C[C@@H](NC(=O)C1(NC(=O)OC(C)(C)C)CCC(=O)CC1)c1ccc(F)cc1
HCID58292041

未命名化合物

PROCEDURE

实验过程

1-(tert-Butoxycarbonylamino)-4-oxocyclohexanecarboxylic acid (750 mg) was coupled with (R)-1-(4-fluorophenyl)ethanamine using the HATU procedure as described in Example 1. The crude was chromatographed with gradient elution 15-80% ethyl acetate in heptane to yield the title compound (900 mg). MS MH+ 379.3

WORKUP

后处理

  1. customThe crude was chromatographed with gradient elution 15-80% ethyl acetate in heptane