HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R)-(+)-1-(4-Fluorophenyl)ethylamine → HCID 58292041, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R)-(+)-1-(4-Fluorophenyl)ethylamine | HCID 6950187 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-(((Tert-butoxy)carbonyl)amino)-4-oxocyclohexane-1-carboxylic acid | HCID 24729768 | — |
| Product | HCID 58292041 | HCID 58292041 | — |
Reaction Steps
1-(tert-Butoxycarbonylamino)-4-oxocyclohexanecarboxylic acid (750 mg) was coupled with (R)-1-(4-fluorophenyl)ethanamine using the HATU procedure as described in Example 1. The crude was chromatographed with gradient elution 15-80% ethyl acetate in heptane to yield the title compound (900 mg). MS MH+ 379.3
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394858B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-143c48bda12c4699adbb005f15c21c27 |
| Source note | uspto-grants-2013_03 |