反应详情

Intermediate 36 (0.221 g, 0.7752 mmol) was reacted with K2CO3 (0.7752 mmol, 0.107 g) in 12 mL of 2:1 MeOH:Water at room temperature overnight. The reaction was worked up quenching the reaction with 1× saturated NaHCO3, extracted 4×25 ml EtOAc then washed 1× water, 1× saturated NaCl, dried over Na2SO4, then concentrated. The product was purified 0-10% MeOH in DCM over 15 min on TEA silica 12 g. ES/MS calcd. for C12H15NO 189.1. Found m/z=190 (M+H)+.

1. customat room temperature
2. customovernight
3. customThe reaction was worked up quenching
4. customthe reaction with 1× saturated NaHCO3
5. extractionextracted 4×25 ml EtOAc
6. washthen washed 1× water, 1× saturated NaCl
7. dry with materialdried over Na2SO4
8. concentrationconcentrated
9. customThe product was purified 0-10% MeOH in DCM over 15 min on TEA silica 12 g