1-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazine → 6-((3-(4-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazine-1-carbonyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide
Reaction equation
OCCCCCC[CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:14]=[C:15]([S:19]([C:22]2[CH:23]=[C:24]3[C:29](=[C:30]([CH3:32])[CH:31]=2)[N:28]=[CH:27][C:26]([C:33]([NH2:35])=[O:34])=[C:25]3[NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=2)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1)=[O:12].[Si:45]([O:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][N:59]1CCN[CH2:61][CH2:60]1)([C:48]([CH3:51])([CH3:50])[CH3:49])([CH3:47])[CH3:46]>>[Si:45]([O:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][N:59]1[CH2:8][CH2:9][N:10]([C:11]([C:13]2[CH:14]=[C:15]([S:19]([C:22]3[CH:23]=[C:24]4[C:29](=[C:30]([CH3:32])[CH:31]=3)[N:28]=[CH:27][C:26]([C:33]([NH2:35])=[O:34])=[C:25]4[NH:36][C:37]3[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=3)(=[O:20])=[O:21])[CH:16]=[CH:17][CH:18]=2)=[O:12])[CH2:61][CH2:60]1)([C:48]([CH3:51])([CH3:50])[CH3:49])([CH3:47])[CH3:46]Participants
3
Reactant 2
Product 1
Procedure
The title compound was synthesized in a manner analogous to that described for Intermediate 70, using Intermediate 25 in place of 8-aminooctanol. ES/MS calcd. for C41H56N5O6SSi+ 774.4. Found m/z=774.5 (M+H)+.
Sources & evidence
- ORD record
- ord-3ee09bbbf05f4962a81c7a33f6a54e5a
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08394829B2
Reaction notes
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