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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1944905Generated: October 31, 2026

1-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazine → 6-((3-(4-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazine-1-carbonyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

https://huagongshe.com/reaction/1944905

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazineHCID 57516931—
Reactant6-[[3-[(8-Hydroxyoctyl)carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamideHCID 66988028—
Product6-((3-(4-(6-((Tert-butyldimethylsilyl)oxy)hexyl)piperazine-1-carbonyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 66988288—

Reaction Steps

The title compound was synthesized in a manner analogous to that described for Intermediate 70, using Intermediate 25 in place of 8-aminooctanol. ES/MS calcd. for C41H56N5O6SSi+ 774.4. Found m/z=774.5 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08394829B2
Source datasetuspto-grants-2013_03
ORD IDord-3ee09bbbf05f4962a81c7a33f6a54e5a
Source noteuspto-grants-2013_03