Methyl 4-(4'-amino-[1,1'-biphenyl]-4-yl)butanoate → Methyl 4-(4'-(3-((3-carbamoyl-4-((3-methoxyphenyl)amino)-8-methylquinolin-6-yl)sulfonyl)benzamido)-[1,1'-biphenyl]-4-yl)butanoate

HRID 1944906Notes

Reaction equation

HRID 1944906 reaction equation
OCCCCC[CH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[CH:14]=[C:15]([S:19]([C:22]2[CH:23]=[C:24]3[C:29](=[C:30]([CH3:32])[CH:31]=2)[N:28]=[CH:27][C:26]([C:33]([NH2:35])=[O:34])=[C:25]3[NH:36][C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=2)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1)=[O:12].NC1C=C[C:49]([C:52]2[CH:57]=[CH:56][C:55]([CH2:58][CH2:59][CH2:60][C:61]([O:63][CH3:64])=[O:62])=[CH:54][CH:53]=2)=[CH:48][CH:47]=1>>[C:33]([C:26]1[CH:27]=[N:28][C:29]2[C:24]([C:25]=1[NH:36][C:37]1[CH:42]=[CH:41][CH:40]=[C:39]([O:43][CH3:44])[CH:38]=1)=[CH:23][C:22]([S:19]([C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[C:11]([NH:10][C:9]1[CH:8]=[CH:7][C:49]([C:52]3[CH:57]=[CH:56][C:55]([CH2:58][CH2:59][CH2:60][C:61]([O:63][CH3:64])=[O:62])=[CH:54][CH:53]=3)=[CH:48][CH:47]=1)=[O:12])(=[O:21])=[O:20])=[CH:31][C:30]=2[CH3:32])(=[O:34])[NH2:35]

Participants

3

Reactant 2

HCID 57516934Methyl 4-(4'-amino-[1,1'-biphenyl]-4-yl)butanoateHCID 669880286-[[3-[(8-Hydroxyoctyl)carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide

Product 1

HCID 66988342Methyl 4-(4'-(3-((3-carbamoyl-4-((3-methoxyphenyl)amino)-8-methylquinolin-6-yl)sulfonyl)benzamido)-[1,1'-biphenyl]-4-yl)butanoate

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 70, using Intermediate 29 in place of 8-aminooctanol. ES/MS calcd. for C42H39N4O7S+ 743.3. Found m/z=743.4 (M+H)+.

Sources & evidence

ORD record
ord-bf6d36d5bcb042ea9cc36f317f7d6ae0
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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