6-((3-((4'-(4-Hydroxybutyl)-[1,1'-biphenyl]-4-yl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → 6-((3-((4'-(4-Hydroxybutyl)-(1,1'-biphenyl]-3-yl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

HRID 1944911Notes

Reaction equation

HRID 1944911 reaction equation
OCCCCC1C=CC(C2C=CC(NC(C3C=C(S(C4C=C5C(=C(C)C=4)N=CC(C(N)=O)=C5NC4C=CC=C(OC)C=4)(=O)=O)C=CC=3)=O)=CC=2)=CC=1.[C:53]([C:56]1[CH:57]=[N:58][C:59]2[C:64]([C:65]=1[NH:66][C:67]1[CH:72]=[CH:71][CH:70]=[C:69]([O:73][CH3:74])[CH:68]=1)=[CH:63][C:62]([S:75]([C:78]1[CH:79]=[C:80]([CH:103]=[CH:104][CH:105]=1)[C:81]([NH:83][C:84]1[CH:85]=[C:86]([C:90]3[CH:95]=[CH:94][C:93]([CH2:96][CH2:97][CH2:98][C:99](OC)=[O:100])=[CH:92][CH:91]=3)[CH:87]=[CH:88][CH:89]=1)=[O:82])(=[O:77])=[O:76])=[CH:61][C:60]=2[CH3:106])(=[O:55])[NH2:54]>>[OH:100][CH2:99][CH2:98][CH2:97][CH2:96][C:93]1[CH:94]=[CH:95][C:90]([C:86]2[CH:87]=[CH:88][CH:89]=[C:84]([NH:83][C:81]([C:80]3[CH:79]=[C:78]([S:75]([C:62]4[CH:63]=[C:64]5[C:59](=[C:60]([CH3:106])[CH:61]=4)[N:58]=[CH:57][C:56]([C:53]([NH2:54])=[O:55])=[C:65]5[NH:66][C:67]4[CH:72]=[CH:71][CH:70]=[C:69]([O:73][CH3:74])[CH:68]=4)(=[O:76])=[O:77])[CH:105]=[CH:104][CH:103]=3)=[O:82])[CH:85]=2)=[CH:91][CH:92]=1

Participants

3

Reactant 2

HCID 669883466-((3-((4'-(4-Hydroxybutyl)-[1,1'-biphenyl]-4-yl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 66988954Methyl 4-(3'-(3-((3-carbamoyl-4-((3-methoxyphenyl)amino)-8-methylquinolin-6-yl)sulfonyl)benzamido)-[1,1'-biphenyl]-4-yl)butanoate

Product 1

HCID 669881406-((3-((4'-(4-Hydroxybutyl)-(1,1'-biphenyl]-3-yl)carbamoyl)phenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 90, using Intermediate 87 as a substrate. ES/MS calcd. for C41H39N4O6S+ 715.3. Found m/z=715.4 (M+H)+.

Sources & evidence

ORD record
ord-675db68bbcc641308e17afae68ad4403
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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