HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-[3-[[4-(2-Hydroxyethyl)piperazin-1-yl]carbonyl]-benzenesulfonyl]-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxyamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 3-(3-Carbamoyl-4-(3-methoxyphenylamino)-8-methylquinolin-6-ylsulfonyl)benzoic acid | HCID 57763288 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-[3-[[4-(2-Hydroxyethyl)piperazin-1-yl]carbonyl]-benzenesulfonyl]-4-(3-methoxyphenylamino)-8-methylquinoline-3-carboxyamide | HCID 131730296 | — |
Reaction Steps
To a mixture of 2-(piperazin-1-yl)ethanol (160 mg, 1.22 mmol), 3-[3-carbamoyl-4-(3-methoxyphenylamino)-8-methylquinoline-6-sulfonyl]benzoic acid (500 mg, 1.02 mmol), and BOP (540 mg, 1.22 mmol) in 3 mL DMF, TEA (0.34 mL, 3.06 mmol) was added at rt. The reaction mixture was stirred over night. Water was added, and the precipitate was collected by filtration. The filter cake was washed with CH2Cl2, and dried, giving the title compound. ES/MS calcd. for C31H34N5O6S+ 604.2. Found m/z=604.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-50c4a210ca3f4ac589854e983df6b698 |
| Source note | uspto-grants-2013_03 |