反应详情

To a mixture of 2-(piperazin-1-yl)ethanol (160 mg, 1.22 mmol), 3-[3-carbamoyl-4-(3-methoxyphenylamino)-8-methylquinoline-6-sulfonyl]benzoic acid (500 mg, 1.02 mmol), and BOP (540 mg, 1.22 mmol) in 3 mL DMF, TEA (0.34 mL, 3.06 mmol) was added at rt. The reaction mixture was stirred over night. Water was added, and the precipitate was collected by filtration. The filter cake was washed with CH2Cl2, and dried, giving the title compound. ES/MS calcd. for C31H34N5O6S+ 604.2. Found m/z=604.2 (M+H)+.

1. additionwas added at rt
2. filtrationthe precipitate was collected by filtration
3. washThe filter cake was washed with CH2Cl2
4. customdried