HRID1944924

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(CCCC#Cc1ccc(NC(=O)C(F)(F)F)cc1)C[C@H](O[Si](C)(C)C(C)(C)C)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505093

未命名化合物

结构：O=C(Nc1ccc(C2(CCCCBr)SCCS2)cc1)C(F)(F)F

HCID58505209

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)O[C@@H](CNCCCCC1(c2ccc(NC(=O)C(F)(F)F)cc2)SCCS1)c1ccc(O)c2[nH]c(=O)ccc12

HCID58505143

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 102, using Intermediate 45 in place of Intermediate 98. ES/MS calcd. for C32H43F3N3O4S2Si+ 682.2. Found m/z=682.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf6edc179f724430acf1d6279960f130
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si:1]([O:8][C@H:9]([C:31]1[CH:40]=[CH:39][C:38]([OH:41])=[C:37]2[C:32]=1[CH:33]=[CH:34][C:35](=[O:42])[NH:36]2)[CH2:10][N:11](C)[CH2:12][CH2:13][CH2:14][C:15]#[C:16][C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])=[CH:19][CH:18]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].BrCCCCC1(C2C=CC(NC(=O)C(F)(F)F)=CC=2)[S:52][CH2:51][CH2:50][S:49]1>>[Si:1]([O:8][C@H:9]([C:31]1[CH:40]=[CH:39][C:38]([OH:41])=[C:37]2[C:32]=1[CH:33]=[CH:34][C:35](=[O:42])[NH:36]2)[CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:29])[C:25]([F:27])([F:26])[F:28])=[CH:19][CH:18]=2)[S:52][CH2:51][CH2:50][S:49]1)([C:4]([CH3:6])([CH3:5])[CH3:7])([CH3:3])[CH3:2]