HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide → (R)-N-(4-(2-(4-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl)-1,3-dithiolan-2-yl)phenyl)-2,2,2-trifluoroacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)(methyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide | HCID 58505093 | — |
| Reactant | N-(4-(2-(4-bromobutyl)-1,3-dithiolan-2-yl)phenyl)-2,2,2-trifluoroacetamide | HCID 58505209 | — |
| Product | (R)-N-(4-(2-(4-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)butyl)-1,3-dithiolan-2-yl)phenyl)-2,2,2-trifluoroacetamide | HCID 58505143 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described for Intermediate 102, using Intermediate 45 in place of Intermediate 98. ES/MS calcd. for C32H43F3N3O4S2Si+ 682.2. Found m/z=682.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-cf6edc179f724430acf1d6279960f130 |
| Source note | uspto-grants-2013_03 |