1-(4-((6-Bromohexyl)oxy)butyl)-4-nitrobenzene → (R)-8-hydroxy-5-(2,2,3,3-tetramethyl-18-(4-nitrophenyl)-4,14-dioxa-7-aza-3-silaoctadecan-5-yl)quinolin-2(1H)-one

HRID 1944925Notes

Reaction equation

HRID 1944925 reaction equation
[Si:1]([O:8][C@H:9]([C:31]1[CH:40]=[CH:39][C:38]([OH:41])=[C:37]2[C:32]=1[CH:33]=[CH:34][C:35](=[O:42])[NH:36]2)[CH2:10][N:11]([CH3:30])CCCC#CC1C=CC(NC(=O)C(F)(F)F)=CC=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].BrC[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][O:50][CH2:51][CH2:52][CH2:53][CH2:54][C:55]1[CH:60]=[CH:59][C:58]([N+:61]([O-:63])=[O:62])=[CH:57][CH:56]=1>>[OH:41][C:38]1[CH:39]=[CH:40][C:31]([C@H:9]([CH2:10][NH:11][CH2:30][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][O:50][CH2:51][CH2:52][CH2:53][CH2:54][C:55]2[CH:60]=[CH:59][C:58]([N+:61]([O-:63])=[O:62])=[CH:57][CH:56]=2)[O:8][Si:1]([CH3:3])([CH3:2])[C:4]([CH3:6])([CH3:7])[CH3:5])=[C:32]2[C:37]=1[NH:36][C:35](=[O:42])[CH:34]=[CH:33]2

Participants

3

Reactant 2

HCID 200714241-(4-((6-Bromohexyl)oxy)butyl)-4-nitrobenzeneHCID 58505093HCID 58505093, compound

Product 1

HCID 58505188(R)-8-hydroxy-5-(2,2,3,3-tetramethyl-18-(4-nitrophenyl)-4,14-dioxa-7-aza-3-silaoctadecan-5-yl)quinolin-2(1H)-one

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 102, using Intermediate 52 in place of Intermediate 45. ES/MS calcd. for C33H50N3O6Si+ 612.4. Found m/z=612.5 (M+H)+.

Sources & evidence

ORD record
ord-51a38937c26340a3bfc8825a142d9f3c
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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