HCID 58505051, compound → HCID 58505108, compound

HRID 1944926Notes

Reaction equation

HRID 1944926 reaction equation
[C:1]([O:5][C:6]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C@@H:20]([O:50][Si:51]([C:54]([CH3:57])([CH3:56])[CH3:55])([CH3:53])[CH3:52])[CH2:21][N:22]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][O:36][CH2:37][CH2:38][CH2:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([N+:47]([O-])=O)=[CH:43][CH:42]=2)[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[C:13]2[C:18]=1[NH:17][C:16](=[O:19])[CH:15]=[CH:14]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:47][C:44]1[CH:43]=[CH:42][C:41]([CH2:40][CH2:39][CH2:38][CH2:37][O:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][N:22]([CH2:21][C@@H:20]([C:12]2[CH:11]=[CH:10][C:9]([O:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[C:18]3[C:13]=2[CH:14]=[CH:15][C:16](=[O:19])[NH:17]3)[O:50][Si:51]([C:54]([CH3:57])([CH3:56])[CH3:55])([CH3:53])[CH3:52])[C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:46][CH:45]=1

Participants

5

Reactant 2

HCID 58505051HCID 58505051, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58505108HCID 58505108, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of Pd/C (10% w/w, 15 mg) and Intermediate 107 (0.25 g, 0.31 mmol) in MeOH (4 mL) was stirred under a balloon of hydrogen gas for 30 minutes, followed by filtration of the mixture through a pad of Celite diatomaceous earth, and concentration under reduced pressure. The title compound was provided as a white foam (0.13 g, 54%). ES/MS calcd. for C43H68N3O8Si+ 782.5. Found m/z=782.6 (M+H)+.

Workup

  1. filtrationfollowed by filtration of the mixture through a pad of Celite diatomaceous earth, and concentration under reduced pressure

Sources & evidence

ORD record
ord-23e565bbfc2f4984b92757c4c9257f50
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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