1-[2-[(6-Bromohexyl)oxy]ethyl]-4-nitrobenzene → (R)-8-hydroxy-5-(2,2,3,3-tetramethyl-16-(4-nitrophenyl)-4,14-dioxa-7-aza-3-silahexadecan-5-yl)quinolin-2(1H)-one

HRID 1944927Notes

Reaction equation

HRID 1944927 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:13]([CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH2:31]CCCC2C=CC([N+]([O-])=O)=CC=2)[O:14][Si:15]([CH3:21])([CH3:20])[C:16]([CH3:19])([CH3:18])[CH3:17])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]=[CH:7]2.BrCCCCCCOC[CH2:53][C:54]1[CH:59]=[CH:58][C:57]([N+:60]([O-:62])=[O:61])=[CH:56][CH:55]=1>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:13]([CH2:22][NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH2:31][CH2:53][C:54]2[CH:59]=[CH:58][C:57]([N+:60]([O-:62])=[O:61])=[CH:56][CH:55]=2)[O:14][Si:15]([CH3:20])([CH3:21])[C:16]([CH3:17])([CH3:19])[CH3:18])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH:8]=[CH:7]2

Participants

3

Reactant 2

HCID 135927841-[2-[(6-Bromohexyl)oxy]ethyl]-4-nitrobenzeneHCID 58505188(R)-8-hydroxy-5-(2,2,3,3-tetramethyl-18-(4-nitrophenyl)-4,14-dioxa-7-aza-3-silaoctadecan-5-yl)quinolin-2(1H)-one

Product 1

HCID 58505219(R)-8-hydroxy-5-(2,2,3,3-tetramethyl-16-(4-nitrophenyl)-4,14-dioxa-7-aza-3-silahexadecan-5-yl)quinolin-2(1H)-one

Procedure

The title compound was synthesized in a manner analogous to that described for Intermediate 106, using Intermediate 53 in place of Intermediate 52. ES/MS calcd. for C31H46N3O6Si+ 584.3. Found m/z=584.4 (M+H)+.

Sources & evidence

ORD record
ord-b67de987fe1f4c61ad46c14e1d3a1d20
Source dataset
uspto-grants-2013_03
Patent number
US08394829B2

Reaction notes

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