HRID1944969

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](C)(C)OCc1cc([C@@H](O)CN)ccc1O

HCID58505193

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(CCCCC=O)cc5)c4)cc23)c1

HCID58505243

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)cc23)c1

HCID86659116

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)Nc5ccc(CCCCCNC[C@H](O)c6ccc(O)c(CO[Si](C)(C)C(C)(C)C)c6)cc5)c4)cc23)c1

HCID58505142

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 148, using Intermediate 9 in place of Intermediate 2 and Intermediate 120 in place of Intermediate 112. ES/MS calcd. for C51H62N5O8SSi+ 932.40. Found m/z=932.4 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ab937c7fcf5a4594a4b379b7eb8c233b
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si](O[C@H](C1C=CC(O)=C2C=1C=CC(=O)N2)CNCCCCCCCCNC(C1C=C(S(C2C=C3C(=C(C)C=2)N=CC(C(N)=O)=C3NC2C=CC=C(OC)C=2)(=O)=O)C=CC=1)=O)(C(C)(C)C)(C)C.[NH2:67][CH2:68][C@@H:69]([C:71]1[CH:76]=[CH:75][C:74]([OH:77])=[C:73]([CH2:78][O:79][Si:80]([C:83]([CH3:86])([CH3:85])[CH3:84])([CH3:82])[CH3:81])[CH:72]=1)[OH:70].[CH3:87][O:88][C:89]1[CH:90]=[C:91]([NH:95][C:96]2[C:105]3[C:100](=[C:101]([CH3:130])[CH:102]=[C:103]([S:106]([C:109]4[CH:114]=[CH:113][CH:112]=[C:111]([C:115](=[O:129])[NH:116][C:117]5[CH:122]=[CH:121][C:120]([CH2:123][CH2:124][CH2:125][CH2:126][CH:127]=O)=[CH:119][CH:118]=5)[CH:110]=4)(=[O:108])=[O:107])[CH:104]=3)[N:99]=[CH:98][C:97]=2[C:131]([NH2:133])=[O:132])[CH:92]=[CH:93][CH:94]=1>>[Si:80]([O:79][CH2:78][C:73]1[CH:72]=[C:71]([C@@H:69]([OH:70])[CH2:68][NH:67][CH2:127][CH2:126][CH2:125][CH2:124][CH2:123][C:120]2[CH:121]=[CH:122][C:117]([NH:116][C:115]([C:111]3[CH:110]=[C:109]([S:106]([C:103]4[CH:104]=[C:105]5[C:100](=[C:101]([CH3:130])[CH:102]=4)[N:99]=[CH:98][C:97]([C:131]([NH2:133])=[O:132])=[C:96]5[NH:95][C:91]4[CH:92]=[CH:93][CH:94]=[C:89]([O:88][CH3:87])[CH:90]=4)(=[O:107])=[O:108])[CH:114]=[CH:113][CH:112]=3)=[O:129])=[CH:118][CH:119]=2)[CH:76]=[CH:75][C:74]=1[OH:77])([C:83]([CH3:86])([CH3:85])[CH3:84])([CH3:81])[CH3:82]