HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(2-Amino-1-hydroxyethyl)-2-[[(tert-butyldimethylsilyl)oxy]methyl]phenol → (R)-6-[[3-[[4-[5-[[2-[3-[[(tert-Butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]pentyl]phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(2-Amino-1-hydroxyethyl)-2-[[(tert-butyldimethylsilyl)oxy]methyl]phenol | HCID 58505193 | — |
| Reactant | 4-[(3-Methoxyphenyl)amino]-8-methyl-6-[[3-[[4-(5-oxopentyl)phenyl]carbamoyl]phenyl]sulfonyl]quinoline-3-carboxamide | HCID 58505243 | — |
| Reactant | (R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 86659116 | — |
| Product | (R)-6-[[3-[[4-[5-[[2-[3-[[(tert-Butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]pentyl]phenyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 58505142 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described for Intermediate 148, using Intermediate 9 in place of Intermediate 2 and Intermediate 120 in place of Intermediate 112. ES/MS calcd. for C51H62N5O8SSi+ 932.40. Found m/z=932.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-ab937c7fcf5a4594a4b379b7eb8c233b |
| Source note | uspto-grants-2013_03 |