HRID1944978

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24996153

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(CN(C)C(=O)c5cccc(CC(C)=O)c5)c4)cc23)c1

HCID66988281

未命名化合物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(C(=O)NCCCCCCCCNC[C@H](O[Si](C)(C)C(C)(C)C)c5ccc(O)c6[nH]c(=O)ccc56)c4)cc23)c1

HCID86659116

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(Nc2c(C(N)=O)cnc3c(C)cc(S(=O)(=O)c4cccc(CN(C)C(=O)c5cccc(CC(C)NC[C@H](O)c6ccc(O)c7[nH]c(=O)ccc67)c5)c4)cc23)c1

HCID54588312

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described for Intermediate 148, using Intermediate 6 in place of Intermediate 2 and Intermediate 137 in place of Intermediate 112.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0547ff482ba64bcb90258e8e757089d7
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394829B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Si](O[C@H](C1C=CC(O)=C2C=1C=CC(=O)N2)CNCCCCCCCCNC(C1C=C(S(C2C=C3C(=C(C)C=2)N=CC(C(N)=O)=C3NC2C=CC=C(OC)C=2)(=O)=O)C=CC=1)=O)(C(C)(C)C)(C)C.[NH2:67][CH2:68][C@@H:69]([C:71]1[CH:80]=[CH:79][C:78]([OH:81])=[C:77]2[C:72]=1[CH:73]=[CH:74][C:75](=[O:82])[NH:76]2)[OH:70].[CH3:83][O:84][C:85]1[CH:86]=[C:87]([NH:91][C:92]2[C:101]3[C:96](=[C:97]([CH3:126])[CH:98]=[C:99]([S:102]([C:105]4[CH:110]=[CH:109][CH:108]=[C:107]([CH2:111][N:112]([C:114]([C:116]5[CH:121]=[CH:120][CH:119]=[C:118]([CH2:122][C:123](=O)[CH3:124])[CH:117]=5)=[O:115])[CH3:113])[CH:106]=4)(=[O:104])=[O:103])[CH:100]=3)[N:95]=[CH:94][C:93]=2[C:127]([NH2:129])=[O:128])[CH:88]=[CH:89][CH:90]=1>>[OH:70][C@H:69]([C:71]1[CH:80]=[CH:79][C:78]([OH:81])=[C:77]2[C:72]=1[CH:73]=[CH:74][C:75](=[O:82])[NH:76]2)[CH2:68][NH:67][CH:123]([CH3:124])[CH2:122][C:118]1[CH:117]=[C:116]([CH:121]=[CH:120][CH:119]=1)[C:114]([N:112]([CH2:111][C:107]1[CH:106]=[C:105]([S:102]([C:99]2[CH:100]=[C:101]3[C:96](=[C:97]([CH3:126])[CH:98]=2)[N:95]=[CH:94][C:93]([C:127]([NH2:129])=[O:128])=[C:92]3[NH:91][C:87]2[CH:88]=[CH:89][CH:90]=[C:85]([O:84][CH3:83])[CH:86]=2)(=[O:104])=[O:103])[CH:110]=[CH:109][CH:108]=1)[CH3:113])=[O:115]