HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-5-(2-Amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one → 6-[[3-[[3-[2-[[(R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]propyl]-N-methylbenzamido]methyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-5-(2-Amino-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one | HCID 24996153 | — |
| Reactant | 4-[(3-Methoxyphenyl)amino]-8-methyl-6-[[3-[[3-(2-oxopropyl)phenylcarbonyl(methyl)amino]methyl]phenyl]sulfonyl]quinoline-3-carboxamide | HCID 66988281 | — |
| Reactant | (R)-6-[[3-[[8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl]ethyl]amino]octyl]carbamoyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 86659116 | — |
| Product | 6-[[3-[[3-[2-[[(R)-2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]propyl]-N-methylbenzamido]methyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide | HCID 54588312 | — |
Reaction Steps
The title compound was synthesized in a manner analogous to that described for Intermediate 148, using Intermediate 6 in place of Intermediate 2 and Intermediate 137 in place of Intermediate 112.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394829B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0547ff482ba64bcb90258e8e757089d7 |
| Source note | uspto-grants-2013_03 |