Hydrochloric Acid → HCID 67208761, compound

HRID 1945010Notes

Reaction equation

HRID 1945010 reaction equation
[C:1]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:6]=[CH:5][C:4]([CH2:7][CH:8]([NH:17]C(OC(C)(C)C)=O)[CH2:9][C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])=[CH:3][CH:2]=1.[ClH:31].O1CCOCC1>>[ClH:31].[C:13]([O:12][C:10](=[O:11])[CH2:9][CH:8]([NH2:17])[CH2:7][C:4]1[CH:3]=[CH:2][C:1]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[CH:6][CH:5]=1)([CH3:16])([CH3:14])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59607675HCID 59607675, compound

Product 1

HCID 67208761HCID 67208761, compound

Procedure

To tert-butyl 4-(biphenyl-4-yl)-3-(tert-butoxycarbonylamino)butanoate (110 mg, 0.267 mmol), a solution of 4 M HCl in 1,4-dioxane (0.668 ml, 2.67 mmol) is added. After stirring for 1 h, the reaction mixture is concentrated to give crude 3-amino-4-biphenyl-4-yl-butyric acid tert-butyl ester hydrochloride.

Workup

  1. concentrationthe reaction mixture is concentrated

Sources & evidence

ORD record
ord-2b3d4cde2d4e4107b53d8ec26a1b4a63
Source dataset
uspto-grants-2013_03
Patent number
US08394853B2

Reaction notes

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