HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2R,4R)-4-amino-2-methyl-pentanoic acid ethyl ester trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2R,4R)-4-tert-butoxycarbonylamino-2-methyl-pentanoic acid ethyl ester | HCID 86648195 | — |
| Product | (2R,4R)-4-amino-2-methyl-pentanoic acid ethyl ester trifluoroacetate | HCID 86648194 | — |
Reaction Steps
Next, (2R,4R)-4-tert-butoxycarbonylamino-2-methyl-pentanoic acid ethyl ester (142 mg, 0.548 mmol) is added to trifluoroacetic acid (5 mL). After 10 minutes, the solvent is removed under reduced pressure. Methylene chloride is added and the solvent is removed under reduced pressure to give (2R,4R)-4-amino-2-methyl-pentanoic acid ethyl ester trifluoroacetate. This material is used directly in the subsequent coupling reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08394853B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-5735bac5e33c42fc8bebd19bd510b6c2 |
| Source note | uspto-grants-2013_03 |