Trifluoroacetic acid → 2-Biphenyl-4-ylmethyl-succinic acid 1-methyl ester

HRID 1945054노트

반응식

HRID 1945054 반응식
[CH3:1][O:2][C:3](=[O:26])[CH:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)[CH2:5][C:6]([O:8]C(C)(C)C)=[O:7].FC(F)(F)C(O)=O>>[CH3:1][O:2][C:3](=[O:26])[CH:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)=[CH:16][CH:15]=1)[CH2:5][C:6]([OH:8])=[O:7]

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 684246972-Biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester

생성물 1

HCID 596078292-Biphenyl-4-ylmethyl-succinic acid 1-methyl ester

실험 절차

Next, 2-biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester (160 mg, 0.451 mmol) is added to trifluoroacetic acid (5 mL). After 10 minutes, the solvent is removed under reduced pressure. Methylene chloride is added and the solvent is removed under reduced pressure to give 2-biphenyl-4-ylmethyl-succinic acid 1-methyl ester. This material is used directly in the subsequent coupling reaction.

후처리

  1. customthe solvent is removed under reduced pressure
  2. additionMethylene chloride is added
  3. customthe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-56e8f233877e4889a0e4380acd1b6704
출처 데이터셋
uspto-grants-2013_03
특허 번호
US08394853B2

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