Trifluoroacetic acid → 2-Biphenyl-4-ylmethyl-succinic acid 1-methyl ester

Beteiligte Stoffe

Reaktionsschritte

Next, 2-biphenyl-4-ylmethyl-succinic acid 4-tert-butyl ester 1-methyl ester (160 mg, 0.451 mmol) is added to trifluoroacetic acid (5 mL). After 10 minutes, the solvent is removed under reduced pressure. Methylene chloride is added and the solvent is removed under reduced pressure to give 2-biphenyl-4-ylmethyl-succinic acid 1-methyl ester. This material is used directly in the subsequent coupling reaction.

Herkunft & Nachweise