HCID 66995601, compound → HCID 66995497, compound

HRID 1945191Notes

Reaction equation

HRID 1945191 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[CH:19]([C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:23][CH:22]=1)[OH:20])C1C=CC=CC=1>[Pd].C(O)C>[CH2:30]([S:27]([C:24]1[CH:23]=[CH:22][C:21]([CH:19]([OH:20])[C:10]2[CH:11]=[C:12]([C:15]([F:17])([F:18])[F:16])[CH:13]=[CH:14][C:9]=2[OH:8])=[CH:26][CH:25]=1)(=[O:28])=[O:29])[CH3:31]

Participants

4

Reactant 1

HCID 66995601HCID 66995601, compound

Product 1

HCID 66995497HCID 66995497, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the product from step (iii) (0.225 g), 10% palladium on carbon (0.05 g) in ethanol (20 ml) was hydrogenated at 1 Bar for 45 min. After filtration the solvent was evaporated under reduced pressure. Yield 0.22 g

Workup

  1. filtrationAfter filtration the solvent
  2. customwas evaporated under reduced pressure

Sources & evidence

ORD record
ord-f0509ee8eeb94fe0b15ec3ce14c128c1
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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