HCID 66995601, compound → HCID 66995959, compound

HRID 1945192Notes

Reaction equation

HRID 1945192 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=1[CH:19]([C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:23][CH:22]=1)O)C1C=CC=CC=1>[Pd].C(O)(=O)C.C(O)C>[CH2:30]([S:27]([C:24]1[CH:23]=[CH:22][C:21]([CH2:19][C:10]2[CH:11]=[C:12]([C:15]([F:17])([F:16])[F:18])[CH:13]=[CH:14][C:9]=2[OH:8])=[CH:26][CH:25]=1)(=[O:28])=[O:29])[CH3:31]

Participants

5

Reactant 1

HCID 66995601HCID 66995601, compound

Product 1

HCID 66995959HCID 66995959, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidCatalystHCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of the product from example 3 step (iii) (0.225 g), 10% palladium on carbon (0.05 g) and acetic acid (2 drops) in ethanol (20 ml) was hydrogenated at 3 Bar for 2 h then SBar for 5 h. After filtration the solvent was evaporated under reduced pressure. Yield 0.16 g

Workup

  1. waitthen SBar for 5 h
  2. filtrationAfter filtration the solvent
  3. customwas evaporated under reduced pressure

Sources & evidence

ORD record
ord-7e44ec4f35cc4eaab60ac876f36788be
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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