HCID 66995623, compound → HCID 66996064, compound

HRID 1945224Notes

Reaction equation

HRID 1945224 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20]>C(O)(=O)C.[Fe]>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[O:19][CH3:20])[NH2:8]

Participants

4

Reactant 1

HCID 66995623HCID 66995623, compound

Product 1

HCID 66996064HCID 66996064, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Iron powder (2.0 g) was added to a solution of the product from step (i) (1.95 g) in acetic acid (40 ml) and the mixture stirred at RT overnight. The mixture was filtered and the filtrate evaporated under reduced pressure. The residue was partitioned between aqueous sodium hydrogencarbonate soln and ethylacetate, the organics dried and evaporated under reduced pressure.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated under reduced pressure
  3. customThe residue was partitioned between aqueous sodium hydrogencarbonate soln
  4. dry with materialethylacetate, the organics dried
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-c6e4293091d649178ffaca41165c0b40
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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