Ethanesulfonyl chloride → HCID 11153919, compound

HRID 1945225Notes

Reaction equation

HRID 1945225 reaction equation
[CH2:1]([S:3](Cl)(=[O:5])=[O:4])[CH3:2].[NH2:7][C:8]1[CH:30]=[CH:29][C:11]([O:12][C:13]2[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:14]=2[O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])=[C:10]([Cl:31])[CH:9]=1>N1C=CC=CC=1>[Cl:31][C:10]1[CH:9]=[C:8]([NH:7][S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])[CH:30]=[CH:29][C:11]=1[O:12][C:13]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:14]=1[O:15][CH2:16][C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 86659309HCID 86659309, compound

Product 1

HCID 11153919HCID 11153919, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Ethane sulphonyl chloride (0.05 ml) was added to a solution of the product from step (iv) (0.19 g) in pyridine (10 ml) and stirred at RT for 2 h. The solvent was evaporated under reduced pressure and the residue dissolved in DCM (10 ml) and trifluoroacetic acid (10 ml). After stirring at RT for 2 h the solvent was removed and the residue purified by RPHPLC, yield 0.062 g.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue dissolved in DCM (10 ml)
  3. stirringAfter stirring at RT for 2 h the solvent
  4. customwas removed
  5. customthe residue purified by RPHPLC, yield 0.062 g

Sources & evidence

ORD record
ord-a2438dd09420400797294913c5eb5e04
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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