反应详情

温度

100 °C

A mixture of 2-bromo-4-fluoroanisole (6.0 g), 2-chloro-4-methylsulphonylaniline (9.0 g), cesium carbonate (14.7 g), palladium acetate (0.33 g) and 2-(dicyclohexylphosphino)-2′,4′,6′-tri-1-propyl-1,1′-biphenyl (0.54 g) in dioxane (60 ml) was heated at 100° C. for 20 h. The mixture was cooled, and partitioned between ethylacetate/water. The organics were separated, washed with brine, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane. Yield 3.2 g

1. temperatureThe mixture was cooled
2. custompartitioned between ethylacetate/water
3. customThe organics were separated
4. washwashed with brine
5. customdried
6. customevaporated under reduced pressure
7. customThe residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane