Sodium Hydroxide → HCID 58516124, compound

HRID 1945233Notes

Reaction equation

HRID 1945233 reaction equation
[OH-].[Na+].[Cl:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH2:9][C:10]([O:12]C)=[O:11])=[C:6]([O:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:25])=[O:24])=[C:19]([C:27]([F:30])([F:29])[F:28])[CH:18]=2)[CH:5]=1>CO.O1CCCC1>[Cl:3][C:4]1[CH:15]=[CH:14][C:7]([O:8][CH2:9][C:10]([OH:12])=[O:11])=[C:6]([O:16][C:17]2[CH:22]=[CH:21][C:20]([S:23]([CH3:26])(=[O:24])=[O:25])=[C:19]([C:27]([F:29])([F:28])[F:30])[CH:18]=2)[CH:5]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86659310HCID 86659310, compound

Product 1

HCID 58516124HCID 58516124, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

1M Sodium hydroxide solution (0.5 m) was added to a solution of the product from step (iii) (0.197 g) in methanol (1 ml) and tetrahydrofuran (3 ml) and stirred at RT for 16 h. The solvent was evaporated under reduced pressure and the residue partitioned between DCM/2M hydrochloric acid. The organics were dried, evaporated under reduced pressure and the residue recrystallised from DCM-isohexane, yield 0.108 g.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue partitioned between DCM/2M hydrochloric acid
  3. customThe organics were dried
  4. customevaporated under reduced pressure
  5. customthe residue recrystallised from DCM-isohexane, yield 0.108 g

Sources & evidence

ORD record
ord-5fcd8fe4bab24017b017bafa34d6d302
Source dataset
uspto-grants-2013_03
Patent number
US08394986B2

Reaction notes

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