Sodium Sulfate → 2-Hexanone, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

HRID 1945256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1945256
IC1C=CC=CC=1S([O-])(=O)=O.[Na+].OOS([O-])=O.[K+].S([O-])([O-])(=O)=O.[Na+].[Na+].[Si:26]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][CH:38]([OH:40])[CH3:39])([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27]>C(OCC)(=O)C>[Si:26]([O:33][CH2:34][CH2:35][CH2:36][CH2:37][C:38](=[O:40])[CH3:39])([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27]

Komponenten

6

Edukt 4

HCID 24436Sodium SulfateHCID 103766662-Hexanol, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-HCID 23662047Sodium 2-IodobenzenesulfonateHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 109223462-Hexanone, 6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-Ausbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

6.1 mg (0.02 mmol) sodium 2-iodobenzenesulfonate prepared by Preparation Example 4, 0.49 g (0.8 mmol) of powdered Oxone (registered trademark), 0.5 g (3.5 mmol) of anhydrous sodium sulfate and 232 mg (1 mmol) of 6-(tert-butyldimethylsilyloxy)hexan-2-ol were added to 5 ml of ethyl acetate, and the mixture was heated at 70° C. while being stirred under a nitrogen for seven hours. The later treatment was carried out in the same way as in Example 1, and then 6-(tert-butyldimethylsilyloxy)hexan-2-one was obtained. The yield of the obtained 6-(tert-butyldimethylsilyloxy)hexan-2-one was determined and the result is shown in Table 2. (Yield 90%)

Quellen und Nachweise

ORD-Eintrag
ord-091992d542294508a492a38214f810a3
Quelldatensatz
uspto-grants-2013_03
Patentnummer
US08394995B2

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