HRID1945964

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID51361321

未命名化合物

结构：Cn1c(CN2CCC(C(C)(C)O)CC2)nc2c(N3CCOCC3)nc(Cl)nc21

HCID59603426

未命名化合物

PRODUCTS

生成物

结构：CC(C)n1c(=O)c2ccccc2n1-c1nc(N2CCOCC2)c2nc(CN3CCC(C(C)(C)O)CC3)n(C)c2n1

HCID59605432

未命名化合物

PROCEDURE

实验过程

Following General Procedure I for Buchwald coupling, 2-isopropyl-1,2-dihydroindazol-3-one and 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol were reacted to give 443. LCMS m/z: 549.3 (MH+)

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-79a790d17b3248e5bd9c64c99464ce19
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394796B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH:1]([N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]1)([CH3:3])[CH3:2].Cl[C:15]1[N:23]=[C:22]2[C:18]([N:19]=[C:20]([CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([C:32]([OH:35])([CH3:34])[CH3:33])[CH2:28][CH2:27]3)[N:21]2[CH3:24])=[C:17]([N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)[N:16]=1>>[OH:35][C:32]([CH:29]1[CH2:28][CH2:27][N:26]([CH2:25][C:20]2[N:21]([CH3:24])[C:22]3[C:18]([N:19]=2)=[C:17]([N:36]2[CH2:37][CH2:38][O:39][CH2:40][CH2:41]2)[N:16]=[C:15]([N:5]2[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:12](=[O:13])[N:4]2[CH:1]([CH3:3])[CH3:2])[N:23]=3)[CH2:31][CH2:30]1)([CH3:34])[CH3:33]