Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Propan-2-yl)-2,3-dihydro-1H-indazol-3-one → 1-(8-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-9-methyl-6-morpholino-9H-purin-2-yl)-2-isopropyl-1H-indazol-3(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Propan-2-yl)-2,3-dihydro-1H-indazol-3-one | HCID 51361321 | — |
| 반응물 | 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol | HCID 59603426 | — |
| 생성물 | 1-(8-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-9-methyl-6-morpholino-9H-purin-2-yl)-2-isopropyl-1H-indazol-3(2H)-one | HCID 59605432 | — |
반응 단계
Following General Procedure I for Buchwald coupling, 2-isopropyl-1,2-dihydroindazol-3-one and 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol were reacted to give 443. LCMS m/z: 549.3 (MH+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08394796B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-79a790d17b3248e5bd9c64c99464ce19 |
| 출처 메모 | uspto-grants-2013_03 |