HRID1946039

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)C(C)(C)N1CCC(Cc2nc3c(N4CCOCC4)nc(-n4c(C)nc5ccccc54)nc3n2C)CC1

HCID59605359

未命名化合物

PRODUCTS

生成物

结构：Cc1nc2ccccc2n1-c1nc(N2CCOCC2)c2nc(CC3CCN(C(C)(C)C(=O)O)CC3)n(C)c2n1

HCID59606019

未命名化合物

PROCEDURE

实验过程

Following the procedure for 506, the methyl ester of methyl 2-methyl-2-(4-((9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-6-morpholino-9H-purin-8-yl)methyl)piperidin-1-yl)propanoate 507 was hydrolyzed with lithium hydroxide to give 525. LCMS m/z: 267.2 (2M+H+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9f18589d41c14bb5a3f2d73a664a2409
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08394796B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH3:1][C:2]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[N:16]([CH3:40])[C:17]3[C:22]([N:23]=2)=[C:21]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[N:20]=[C:19]([N:30]2[C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=4[N:32]=[C:31]2[CH3:39])[N:18]=3)[CH2:10][CH2:9]1)([CH3:7])[C:3]([O:5]C)=[O:4].[OH-].[Li+]>>[CH3:7][C:2]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[N:16]([CH3:40])[C:17]3[C:22]([N:23]=2)=[C:21]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[N:20]=[C:19]([N:30]2[C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=4[N:32]=[C:31]2[CH3:39])[N:18]=3)[CH2:10][CH2:9]1)([CH3:1])[C:3]([OH:5])=[O:4]