反应详情

A solution of N-[1-({2-chloro-6-[(phenylmethyl)oxy]phenyl}methyl)-1H-pyrazol-3-yl]-2,6-difluorobenzamide (for a preparation see Intermediate 10)(0.148 g, 0.326 mmol) in ethyl acetate (20 ml) was hydrogenated using an H-cube (settings: 20° C., 1 bar, 1 ml/min flow rate) and 5% Pd/C CatCart 30 as the catalyst. The solution was hydrogenated again using an H-cube (settings: 20° C., 1 bar, 1 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was removed in vacuo to give the title compound as a colourless gum (70 mg); LCMS: (System 1) MH+=364, tRET=3.14 min.

1. customThe solvent was removed in vacuo