反应详情

To a slight suspension of 4-methyl-3-(trifluoromethyl)benzoic acid (2.18 g, 10.7 mmol, ABCR) in ethanol (30 ml) was added concentrated sulphuric acid specific gravity 1.84 (0.5 ml, 9.38 mmol). The resulting solution was heated to reflux overnight under nitrogen. The solution was diluted with DCM (100 ml) and then water (100 ml). The phases were separated and the organic extract washed with saturated aqueous sodium hydrogen carbonate (50 ml), dried (MgSO4), filtered and the solvent removed in vacuo to give the title compound as a mobile pale yellow oil (2.27 g); LCMS: (System 4) MH+=233, tRET=3.29 min.

1. temperatureThe resulting solution was heated
2. temperatureto reflux overnight under nitrogen
3. customThe phases were separated
4. extractionthe organic extract
5. washwashed with saturated aqueous sodium hydrogen carbonate (50 ml)
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. customthe solvent removed in vacuo