反应详情

To a solution of methyl 4-chloro-3-[(3-{[(2,6-difluorophenyl)carbonyl]amino}-1H-pyrazol-1-yl)methyl]benzoate (for a preparation see Intermediate 23)(0.95 g, 2.34 mmol) in methanol (20 ml) was added sodium hydroxide (2.4 ml, 4.80 mmol). The reaction was stirred for 4 h, under nitrogen, at ambient temperature. The solvent was evaporated in vacuo, and the residue partitioned between diethyl ether (60 ml) and 2N aqueous HCl (50 ml). The residue was insoluble and the diethyl ether was removed in vacuo. The aqueous suspension was filtered through a hydrophobic frit, and the residue washed with ether and dried under vacuum to give the title compound as a white solid (0.651 g);

1. customThe solvent was evaporated in vacuo
2. customthe residue partitioned between diethyl ether (60 ml) and 2N aqueous HCl (50 ml)
3. customthe diethyl ether was removed in vacuo
4. filtrationThe aqueous suspension was filtered through a hydrophobic frit
5. washthe residue washed with ether
6. customdried under vacuum