Sodium Hydroxide → 4-Chloro-3-[(3-{[(2,6-difluorophenyl)carbonyl]amino}-1H-pyrazol-1-yl)methyl]benzoic acid

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Reaction Steps

To a solution of methyl 4-chloro-3-[(3-{[(2,6-difluorophenyl)carbonyl]amino}-1H-pyrazol-1-yl)methyl]benzoate (for a preparation see Intermediate 23)(0.95 g, 2.34 mmol) in methanol (20 ml) was added sodium hydroxide (2.4 ml, 4.80 mmol). The reaction was stirred for 4 h, under nitrogen, at ambient temperature. The solvent was evaporated in vacuo, and the residue partitioned between diethyl ether (60 ml) and 2N aqueous HCl (50 ml). The residue was insoluble and the diethyl ether was removed in vacuo. The aqueous suspension was filtered through a hydrophobic frit, and the residue washed with ether and dried under vacuum to give the title compound as a white solid (0.651 g);

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