Hydrochloric Acid → HCID 66790072, compound

HRID 1946409Notes

Reaction equation

HRID 1946409 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[N:10]2)=[C:4]([C:24]([F:27])([F:26])[F:25])[CH:3]=1.[ClH:28].O1CCOCC1>CO>[ClH:28].[I:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[CH:13]=[CH:12][C:11]([NH:14][C:15]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][C:18]=3[CH3:23])=[O:16])=[N:10]2)=[C:4]([C:24]([F:27])([F:25])[F:26])[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59547845HCID 59547845, compound

Product 1

HCID 66790072HCID 66790072, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To N-(1-{[4-iodo-2-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-yl)-3-methyl-4-pyridinecarboxamide (for a preparation see Intermediate 39)(20 mg) dissolved in methanol (1 ml) was added 4.0 M hydrochloride in 1,4-dioxane (0.85 ml, 3.40 mmol). The solvent was removed under a stream of nitrogen and dried in a vacuum oven at 40° C. for 1 h to give the title compound as a white solid (19 mg); LCMS: (System 4) MH+=487, tRET=2.51 min.

Workup

  1. customThe solvent was removed under a stream of nitrogen
  2. customdried in a vacuum oven at 40° C. for 1 h

Sources & evidence

ORD record
ord-b30d808e61a949aea3e93c8e873b77f1
Source dataset
uspto-grants-2013_03
Patent number
US08399436B2

Reaction notes

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