Hydrochloric Acid → HCID 23028088, compound

HRID 1946459Notes

Reaction equation

HRID 1946459 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([S:13]([NH2:16])(=[O:15])=[O:14])=[C:9]([CH2:11][CH3:12])[N:10]=2)[N:7]=1.[CH3:17][O-:18].[Na+].Cl>CO>[CH2:11]([C:9]1[N:10]=[C:5]2[CH:4]=[CH:3][C:2]([O:18][CH3:17])=[N:7][N:6]2[C:8]=1[S:13]([NH2:16])(=[O:15])=[O:14])[CH3:12]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 23028090HCID 23028090, compound

Product 1

HCID 23028088HCID 23028088, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6-Chloro-2-ethylimidazo[1,2-b]pyridazin-3-ylsulfonamide (1.50 g, 5.75 mmol) was suspended in methanol (30.0 ml) and stirred at room temperature, during which sodium methoxide (28%, 3.34 g, 17.3 mmol) was added thereto. The mixture was heated for 5 hours under reflux, and then the reaction solution was poured into ice-water (200 ml) and adjusted to pH 2 with conc. hydrochloric acid. The precipitated crystals were filtered and washed with water, to give the title compound as colorless crystals. The yield was 1.02 g (69.3%).

Workup

  1. additionwas added
  2. temperatureThe mixture was heated for 5 hours
  3. temperatureunder reflux
  4. filtrationThe precipitated crystals were filtered
  5. washwashed with water

Sources & evidence

ORD record
ord-470214b39127488394fc814715127a49
Source dataset
uspto-grants-2013_03
Patent number
US08399381B2

Reaction notes

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