HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1,1-dimethylethyl)cyclohepta[d]imidazol-4(1H)-one → 2-(1,1-dimethylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1,1-dimethylethyl)cyclohepta[d]imidazol-4(1H)-one | HCID 58460232 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(1,1-dimethylethyl)-5,6,7,8-tetrahydrocyclohepta[d]imidazol-4(1H)-one | HCID 58460162 | 87.7% |
Reaction Steps
A solution of Intermediate 63 (1.9 g) in methanol (400 mL) was hydrogenated using the H-Cube (settings: room temp, 1.3 ml/min flow rate) and 10% Pd/C CatCart 30 as the catalyst. The solvent was concentrated under vacuum to give the title compound (1.7 g). LC/MS MH+ 207 Rt 0.75 min (5 minute run).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399444B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f663519f2de94d9e803483f48843b53c |
| Source note | uspto-grants-2013_03 |