反应详情

Intermediate 16 (22 mg) was dissolved in Methanol (1 ml) and treated with sodium hydroxide, 2M aq. (1 mL). The RM was left in solution for 1 hour. The residue was purified by MDAP (Method A). The desired fractions were combined and concentrated under nitrogen blowdown to give the title compound (17 mg). LC/MS MH+ 375, Rt 1.72 min (5 minute run).

1. customThe residue was purified by MDAP (Method A)
2. concentrationconcentrated under nitrogen