Sodium Hydroxide → [3-[(4-Chlorophenyl)methyl]-2-(1,1-dimethylethyl)-3,4,5,6,7,8-hexahydrocyclohepta[d]imidazol-4-yl]acetic acid

Participants

Reaction Steps

Intermediate 16 (22 mg) was dissolved in Methanol (1 ml) and treated with sodium hydroxide, 2M aq. (1 mL). The RM was left in solution for 1 hour. The residue was purified by MDAP (Method A). The desired fractions were combined and concentrated under nitrogen blowdown to give the title compound (17 mg). LC/MS MH+ 375, Rt 1.72 min (5 minute run).

Provenance & Evidence