反应详情

To a cooled (0° C.) solution of 6-chloropyrimidine-4-carbonyl chloride in DCM (60 mL), obtained as described above for Intermediate 7, step 1 (798 mg; 4.51 mmol) was added dropwise, during a period of 30 minutes, a solution of 5-aminoindazole (Aldrich, 500 mg; 3.76 mmol) and DIEA (1.29 ml; 7.51 mmol) in dry DMF (5 mL). At the end of addition the reaction mixture was concentrated in vacuo, diluted with water and extracted with EtOAc. A white precipitate separated from the organic phase. It was filtered and dried in vacuo to afford the title compound as a beige solid.

1. customobtained
2. additionwas added dropwise, during a period of 30 minutes
3. additionAt the end of addition the reaction mixture
4. concentrationwas concentrated in vacuo
5. additiondiluted with water
6. extractionextracted with EtOAc
7. customA white precipitate separated from the organic phase
8. filtrationIt was filtered
9. customdried in vacuo